Andrew M. Vontell

This paper compares the chromatin engagement mechanisms of PAX3::FOXO1 and PAX7::FOXO1 fusions in rhabdomyosarcoma using modified MNase ChIP and identifies distinct nucleosome targeting patterns.

The paper identifies PAX3::FOXO1's pioneer function through partial/homeobox motif recognition and its role in initiating neural transcriptional programs in rhabdomyosarcoma.

The paper identifies a TGFBR2 variant in patients with micrognathia and cleft palate, tests its causality in mice, and finds it does not cause craniofacial anomalies, highlighting challenges in translating genetic findings to models.