Benjamin D. Sunkel

This study shows Hat1 regulates H3K9 methylation and HMT localization in LADs, affecting heterochromatin structure and inheritance in mouse cells.

This paper compares the chromatin engagement mechanisms of PAX3::FOXO1 and PAX7::FOXO1 fusions in rhabdomyosarcoma using modified MNase ChIP and identifies distinct nucleosome targeting patterns.

This study shows NR0B1 alters the 9-cis-retinoic acid response in Ewing Sarcoma cells by modulating nuclear receptor activity, suggesting NR0B1 inhibition could enhance retinoid therapy.

The paper uses CRISPR-Sirius to visualize differences in large-scale chromosome conformations between osteoblasts and osteosarcoma cells, revealing regulatory mechanisms involving H3K27me3 and CTCF/cohesin.

PEDIA-BRAIN provides a single nuclei multiomic resource of the human pons across development, revealing oligodendrocyte maturation trajectories and disease-related perturbations in DMG and MS.

The paper introduces a low-cost, flexible method for quantitative chromatin sequencing and enables cross-species epigenomic comparisons.

This study shows that varying levels of PAX3::FOXO1 protein affect cell state and epigenetic heterogeneity in rhabdomyosarcoma.

This study shows HAT1 acetylates new histones during DNA replication, regulating chromatin state inheritance and nuclear lamina-heterochromatin interactions.

This study investigates the chromatin-binding properties of the oncogenic PAX3-FOXO1 fusion protein using pc-ChIP-seq, revealing its pioneer function at repressed chromatin in RMS cells.