Author

Sandra Ciesek

Fraunhofer Institute for Translational Medicine and PharmacologyORCID 0000-0002-1802-7565Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Denisa BojkováiD· 2 shared Jindrich Jr. CinatliD· 2 shared Alpha Tom KodamulliliD· 1 shared Andrea ZalianiiD· 1 shared Bruce T. SchultziD· 1 shared Carsten ClausseniD· 1 shared Christian EbelingiD· 1 shared Christian MünchiD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBioinformatics

Denisa BojkováORCID

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2 papers

Recent·Most cited

The COVID-19 PHARMACOME: A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization

Bruce T. Schultz, Andrea Zaliani, Christian Ebeling, Jeanette Reinshagen, Denisa Bojková, Vanessa Lage‐Rupprecht, Reagon Karki, Soeren Lukassen, Yojana Gadiya, Neal G. Ravindra, Sayoni Das, Shounak Baksi, Daniel Domingo‐Fernándéz, Manuel Lentzen, Mark A. Strivens, , Martin Hofmann‐Apitius

The paper presents a drug-target-mechanism graph to identify synergistic drug combinations for SARS-CoV-2 treatment, validated through experimental testing.

bioRxiv · Sep 23, 2020 · PreprintBioinformatics

Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication

Kevin Klann, Denisa Bojková, Georg Tascher, Sandra Ciesek, Christian Münch, Jindrich Jr. Cinatl

This study identifies growth factor receptor signaling as a key pathway for SARS-CoV-2 replication and shows that inhibiting it prevents viral replication in human cells.

Molecular Cell · Aug 11, 2020Peer-reviewedSystems Biology