Claudia Lalancette

The paper investigates sex-specific molecular responses to early-life toxicant exposures in mice across multiple life stages using transcriptomic and epigenomic data.

The paper investigates whether early-life maternal loss in African savanna elephants leads to accelerated DNA methylation age and distinct epigenetic signatures, finding instead a younger epigenetic age and limited differential methylation.

The paper characterizes persistent epigenomic and transcriptomic changes in mice exposed to environmental toxicants across life stages, revealing widespread gene expression and chromatin alterations.

The paper integrates snATAC-seq and snRNA-seq data from human and rat skeletal muscle to identify cell types, regulatory elements, and SNPs associated with complex traits.

The paper evaluates epigenetic methods using reference materials, finding high concordance between assays and differences in performance across platforms.

This study shows perinatal lead exposure causes sex-specific DNA methylation changes in adult mouse liver and blood, with some methylation sites overlapping between tissues.