Asparagine availability differentially regulates early vs late CD4+ and CD8+ T cell activation, metabolism and autophagy
Mingcheng Song, Linda V. Sinclair, Mary J. Tozer, Mihaela Lorger, Robert J. Salmond
This study shows CD4+ T cells rely more on asparagine uptake than CD8+ T cells for activation, differentiation, metabolism, and autophagy, with CD8+ cells expressing more ASNS.
bioRxiv · Apr 29, 2026 · PreprintImmunology