Abby R. Thurm

Structural probing of RNA hairpins quantifies protein occupancy on RNA and links it to function in human cells

This paper introduces a method to measure RNA structure and protein binding in human cells, showing how RNA folding and sequence determine protein occupancy and function.

Single-cell chromatin state transitions during epigenetic memory formation

The paper investigates chromatin state transitions during epigenetic memory formation by analyzing single-cell gene expression and chromatin structure changes after repressor recruitment and release.

High-throughput development and characterization of new functional nanobodies for gene regulation and epigenetic control in human cells

The paper develops a method to generate functional nanobodies for gene regulation and epigenetic control in human cells, identifying tens of effective nanobodies.

High-throughput discovery of regulatory effector domains in human RNA-binding proteins

The paper identifies hundreds of RNA-regulatory effectors in human RBPs using HT-RNA-Recruit and develops a synthetic RNA regulator with a predictive mathematical model.

Single-molecule chromatin configurations link transcription factor binding to expression in human cells

This study links transcription factor binding to gene expression by analyzing chromatin configurations using single-molecule footprinting in human cells.

High-Throughput Discovery and Characterization of Viral Transcriptional Effectors in Human Cells

The paper identifies and characterizes viral transcriptional effector domains from coronaviruses and herpesviruses using high-throughput assays and perturbations.