Author

Manuel Portero‐Otín

Universitat de LleidaORCID 0000-0002-1823-0299Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Isidró FerreriD· 3 shared Pol Andrés‐BenitoiD· 3 shared Joaquím SoliD· 2 shared Mariona JovéiD· 2 shared Pascual TorresiD· 2 shared Reinald PamplonaiD· 2 shared Abraham Acevedo‐ArozenaiD· 1 shared Alessandro Marrero‐GagliardiiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersNeuroscience

Isidró FerrerORCID

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Author profile →

4 papers

Recent·Most cited

A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia

Cristina Anton-Barros, Beatriz Villarejo‐Zori, Sara Carmona-Lorenzo, Juan Manuel Barbero-Paredes, Daniel González-Díaz, Mónica Uceda, Anna Fernàndez‐Bernal, Manuel Portero‐Otín, Iván Ayuso‐Fernández, Cristina Galiana‐Roselló, Francisco García-García, Elisa Navarro, Jorge Montesinos

This study identifies cholesterol accessibility as a key driver of TLR4-dependent microglial activation, showing that SR-B1 mediates LPS-induced cholesterol uptake and regulates TLR4 signaling and inflammatory responses.

bioRxiv · Sep 14, 2026 · PreprintMolecular Biology

A functional interaction between TDP-43 and USP10 reveals USP10 dysfunction in TDP-43 proteinopathies

Alessandro Marrero‐Gagliardi, Judith Noda, Matteo Zanovello, G Gerenu, José Miguel Brito Armas, Alexander Bampton, Pascual Torres, Haizea Hernández-Eguiazu, S Moragón, F Pellegrini, C Pérez Hernández, Felipe Fumagallo-Reading, L Taoro-González, R Muñoz de Bustillo Alfaro, Anna‐Leigh Brown, , Abraham Acevedo‐Arozena

This study identifies a functional interaction between TDP-43 and USP10, showing USP10 modulates alternative splicing and can reduce TDP-43 toxicity in a mouse model of ALS and FTD.

bioRxiv · Jan 23, 2024 · PreprintNeuroscience

Lipidomic alterations in the cerebral cortex and white matter in sporadic Alzheimer's disease

Èlia Òbis, Joaquím Sol, Pol Andrés‐Benito, Meritxell Martin‐Garí, Natàlia Mota‐Martorell, José Daniel Galo‐Licona, Gerard Piñol‐Ripoll, Manuel Portero‐Otín, Isidró Ferrer, Mariona Jové, Reinald Pamplona

The paper analyzes lipidomic changes in cerebral cortex and white matter of Alzheimer's disease patients, finding distinct lipid profiles associated with disease progression.

Aging and Disease · Jan 1, 2023Peer-reviewedNeuroscience

Nuclear lipidome is altered in amyotrophic lateral sclerosis: a preliminary study

Omar Ramírez‐Núñez, Mariona Jové, Pascual Torres, Joaquím Sol, Laia Fontdevila, Ricardo Romero‐Guevara, Victòria Ayala, Chiara Rossi, Jordi Boada, Mónica Povedano, Pol Andrés‐Benito, Isidró Ferrer, Reinald Pamplona, Manuel Portero‐Otín

This study identifies a differential lipidomic signature in nuclei of ALS patients, linking lipid changes to disease mechanisms.

bioRxiv · Jun 26, 2019 · PreprintNeuroscience