Author

Alasdair T. S. Leeson-Payne

University of AberdeenORCID 0000-0002-1823-2913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Claudia CristianoiD· 2 shared Lora K. HeisleriD· 2 shared Raffaella Chianese· 2 shared Aida MohammadkhaniiD· 1 shared Alexandra M. JohnstoneiD· 1 shared Arimantas LionikasiD· 1 shared Brian LamiD· 1 shared Claire FyfeiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Claudia CristianoORCID

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2 papers

Recent·Most cited

Brain serotonin circuit reverses decline in physical activity with age

Pablo Blanco Martínez de Morentin, Alasdair T. S. Leeson-Payne, Shuwen Mu, Yuliia V. Martynova, Aida Mohammadkhani, Drew M. Neyens, J. Antonio Gonzalez, Jānis Lazovskis, Claudia Cristiano, Daniel R. Crabtree, Claire Fyfe, William Buosi, Daniel Powell, Raffaella Chianese, Matevž Arčon, , Lora K. Heisler

The paper identifies a brain serotonin circuit that contributes to age-related decline in physical activity and shows it can be reversed by targeting specific receptors.

bioRxiv · Dec 27, 2025 · PreprintNeuroscience

Obesity medication lorcaserin requires brainstem GLP-1 neurons to reduce food intake in mice

Stefan Wagner, Daniel I. Brierley, Alasdair T. S. Leeson-Payne, Wanqing Jiang, Raffaella Chianese, Brian Lam, Georgina K.C. Dowsett, Claudia Cristiano, David Lyons, Frank M. Reimann, Fiona M. Gribble, Giles S.H. Yeo, Stefan Trapp, Lora K. Heisler

This study identifies brainstem GLP-1 neurons as essential for lorcaserin's effect on reducing food intake in mice and suggests combination therapy with GLP-1R agonists may enhance efficacy.

bioRxiv · May 6, 2022 · PreprintNeuroscience