Mae G. Weaver

Molecular basis for ligand-gating of the human GluD1 receptor

This study determines the structure of human GluD1 and elucidates its ligand-gating mechanism using cryoEM and electrophysiology.

GluDs are ionotropic dopamine receptors tuned by G-proteins

The paper identifies dopamine as a direct agonist of GluDs, showing G-protein regulation of their activity and implications for neurological diseases.