Author

Evan S. O’Brien

Johns Hopkins UniversityORCID 0000-0002-2260-7722Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Anish Kumar MondaliD· 1 shared Anthony YaneziD· 1 shared Barnali Paul· 1 shared Brian K. KobilkaiD· 1 shared Chunlai CheniD· 1 shared Edward C. TwomeyiD· 1 shared Elisa Cristina CarrilloiD· 1 shared Elizabeth White· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Anish Kumar MondalORCID

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2 papers

Recent·Most cited

GluDs are ionotropic dopamine receptors tuned by G-proteins

Haobo Wang, Mae G. Weaver, Elisa Cristina Carrillo, Iris Zheng, Weiqi Gu, Jeffrey Khau, Anish Kumar Mondal, Anthony Yanez, Evan S. O’Brien, Vasanthi Jayaraman, Edward C. Twomey

The paper identifies dopamine as a direct agonist of GluDs, showing G-protein regulation of their activity and implications for neurological diseases.

bioRxiv · May 13, 2026 · PreprintBiophysics

Discovery and dynamic pharmacology of μ-opioid receptor positive allosteric modulators

Evan S. O’Brien, Junzheng Wang, Parthasaradhireddy Tanguturi, Mengchu Li, Elizabeth White, Yuki Shiimura, Barnali Paul, Kevin Appourchaux, Kaavya Krishna Kumar, Weijiao Huang, Susruta Majumdar, John R. Traynor, John M. Streicher, Chunlai Chen, Brian K. Kobilka

This study discovers μ-opioid receptor positive allosteric modulators (PAMs) and investigates their dynamic mechanism of action to enhance opioid agonist activity while reducing side effects.

bioRxiv · Feb 21, 2026 · PreprintBiophysics