Author

Paul A. Humphreys

University of ManchesterORCID 0000-0002-1833-4864Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Susan J. KimberiD· 5 shared Nicola BatesiD· 4 shared Christopher Andrew SmithiD· 3 shared Fabrizio E. ManciniiD· 3 shared Stuart A. CainiD· 3 shared Woods Jon SiD· 3 shared Mark A NaveniD· 2 shared Aleksandr MironoviD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersDevelopmental Biology

Susan J. KimberORCID

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5 papers

Recent·Most cited

Human pluripotent stem cell model of multiple epiphyseal dysplasia with MATN3 mutation identifies altered Matrix organisation and upregulation of the cholesterol biosynthesis pathway

Woods Jon S, Nicola Bates, Stuart A. Cain, Paul A. Humphreys, Fabrizio E. Mancini, Brenda Aguero Burgos, Peter Harley, Rayed Ali A. Alqahtani, Witchayapon Kamprom, Aleksandr Mironov, Antony D. Adamson, Ian J. Donaldson, Geert R. Mortier, Kate Chandler, Anna Nicolaou, , Susan J. Kimber

This study uses hPSCs to model MED with MATN3 mutations, revealing altered matrix organisation and upregulated cholesterol biosynthesis pathway.

Osteoarthritis and Cartilage · Feb 4, 2026Peer-reviewedCell Biology

Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis

Fabrizio E. Mancini, Paul A. Humphreys, Woods Jon S, Nicola Bates, Sara Cuvertino, Julieta O’Flaherty, Leela Biant, Marco A.N. Domingos, Susan J. Kimber

This study shows that adding TTNPB and timed BMP2 to hPSC differentiation improves chondrogenesis, upregulating genes related to skeletal and cartilage development.

Scientific Reports · Feb 1, 2024Peer-reviewedDevelopmental Biology

SIRT1 activity orchestrates ECM expression during hESC-chondrogenic differentiation

Christopher Andrew Smith, Paul A. Humphreys, Nicola Bates, Mark A Naven, Stuart A. Cain, Mona Dvir‐Ginzberg, Susan J. Kimber

This study shows that SIRT1 activation increases ECM gene expression but reduces GAG retention during hESC chondrogenesis, suggesting a complex role in cartilage development.

The FASEB Journal · Apr 13, 2022Peer-reviewedDevelopmental Biology

Directed differentiation of hPSCs through lateral plate mesoderm for generation of articular cartilage progenitors

Christopher Andrew Smith, Paul A. Humphreys, Mark A Naven, Fabrizio E. Mancini, Susan J. Kimber

This study differentiates human pluripotent stem cells through lateral plate mesoderm to generate articular cartilage progenitors and preosteoblasts in a chemically defined protocol.

bioRxiv · Mar 24, 2021 · PreprintDevelopmental Biology

Optogenetic control of the Bone Morphogenetic Protein signalling pathway through engineered blue light-sensitive receptors

Paul A. Humphreys, Woods Jon S, Christopher Andrew Smith, Nicola Bates, Stuart A. Cain, Robert James Lucas, Susan J. Kimber

This paper develops an optogenetic system to control BMP signaling using blue light, enabling precise and dynamic activation in human cells.

ACS Synthetic Biology · Oct 21, 2020Peer-reviewedMolecular Biology