Sainan Li

This study uses population-based metaproteomics to identify functional associations between gut microbiota and 39 phenotypes, including 1,381 features related to Type 2 Diabetes.

This study identifies H3K27ac as a key transcriptional switch that promotes longevity by enhancing lipid catabolism and antioxidant defenses under hormetic nutrient stress in C. elegans.

This study shows phenformin extends lifespan in C. elegans more consistently than metformin, which is affected by environmental factors like agar batch.

This study identifies ether lipid biosynthesis as a key pathway mediating the longevity benefits of biguanides like metformin in C. elegans.

This study shows that riboflavin depletion in C. elegans extends lifespan and improves metabolic health through multiple pathways.