Sinclair W. Emans

The paper identifies reductive stress as a toxicity of biguanides like metformin, showing that fatty acid biosynthesis protects against this effect and could be targeted in cancer.

This study identifies that impaired ribosomal RNA biogenesis enhances resistance to reductive stress in C. elegans by reducing NADPH/NADH accumulation and GSH levels.

This study shows that AMPK regulates NPP-16/NUP50 to enhance lipid catabolism and extend C. elegans lifespan, independent of its nuclear transport function.

This study identifies ether lipid biosynthesis as a key pathway mediating the longevity benefits of biguanides like metformin in C. elegans.

The paper shows that TORC2 deficiency in C. elegans slows development through the Hh/Patched signaling pathway and the transcription factor pqm-1.

This study shows that riboflavin depletion in C. elegans extends lifespan and improves metabolic health through multiple pathways.