Alexander A. Soukas

C. elegans display antipathy behavior towards food after contemporaneous integration of nutritional needs and dietary lipid availability

This study identifies molecular mechanisms by which C. elegans avoid Methylobacterium after ingestion, integrating lipid metabolism and dietary needs to influence food preference.

Reductive death is averted by an ancient metabolic switch.

The paper identifies reductive stress as a toxicity of biguanides like metformin, showing that fatty acid biosynthesis protects against this effect and could be targeted in cancer.

Ribosomal RNA Synthesis is a Lethal Vulnerability During Reductive Stress In C. elegans

This study identifies that impaired ribosomal RNA biogenesis enhances resistance to reductive stress in C. elegans by reducing NADPH/NADH accumulation and GSH levels.

The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

This study shows that AMPK regulates NPP-16/NUP50 to enhance lipid catabolism and extend C. elegans lifespan, independent of its nuclear transport function.

Hormetic nutrient stress promotes longevity by orchestrating histone acetylation on key lipid catabolism and antioxidant defense genes

This study identifies H3K27ac as a key transcriptional switch that promotes longevity by enhancing lipid catabolism and antioxidant defenses under hormetic nutrient stress in C. elegans.

Phenformin's impact on lifespan in C. elegans is resilient to environmental factors that inhibit metformin-induced longevity downstream of skn-1/Nrf and AMP-activated protein kinase

This study shows phenformin extends lifespan in C. elegans more consistently than metformin, which is affected by environmental factors like agar batch.

Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms

This study identifies ether lipid biosynthesis as a key pathway mediating the longevity benefits of biguanides like metformin in C. elegans.

Target of Rapamycin Complex 2 modulates development through Hedgehog/Patched signaling in C. elegans

The paper shows that TORC2 deficiency in C. elegans slows development through the Hh/Patched signaling pathway and the transcription factor pqm-1.

Riboflavin Depletion Promotes Longevity and Metabolic Hormesis in Caenorhabditis elegans

This study shows that riboflavin depletion in C. elegans extends lifespan and improves metabolic health through multiple pathways.