ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation
Hao Wu, Upneet Kaur, Chengmin Li, Elise N. Muñoz, Geeta J. Narlikar, Yifan Cheng
This study reveals that INO80 reorients on a nucleosome upon ATP hydrolysis, enabling DNA translocation through a unique mechanism distinct from other chromatin remodelers.
bioRxiv · Aug 18, 2026 · PreprintBiophysics