Simai Wang

This study shows that FACT is essential for chromatin replication and transcription by disrupting and reassembling nucleosomes, preventing genome aggregation.

The paper investigates how two chromatin remodelers, ACF and RSC, affect chromatin condensation and dynamics, revealing distinct mesoscale effects on chromatin structure and function.

The paper identifies ELOA-dependent mechanisms regulating transcription maturation and links them to cellular senescence and aging through RNA processing defects and growth arrest.

The paper introduces IDLI, a method to map nucleosome structures and distortion patterns in mammalian chromatin, revealing widespread and regulated DNA accessibility across cell types.

This study introduces RASAM, a method to analyze nascent chromatin structure, finding that newly replicated chromatin is hyperaccessible and has unique organization features.

The paper introduces Mach-1, an RNA foundation model that predicts transcriptome architecture from DNA sequence, validated through experimental perturbations and CRISPR editing.