Megan S Ostrowski

The paper identifies transcription factors and effector genes involved in human cortical neurogenesis using CRISPRi screening in a primary culture system.

The paper investigates how two chromatin remodelers, ACF and RSC, affect chromatin condensation and dynamics, revealing distinct mesoscale effects on chromatin structure and function.

This study introduces RASAM, a method to analyze nascent chromatin structure, finding that newly replicated chromatin is hyperaccessible and has unique organization features.

The paper introduces REMORA, a method to record RNA-protein interactions on single RNA molecules by using RNA deaminases, and shows competition between PUM1 and PUM2 for RNA binding sites.

SMRT-Tag enables low-input, single-molecule sequencing for simultaneous detection of genetic and epigenetic variations in human samples.

This study uses a single-molecule platform to show that SNF2h, a chromatin remodeler, regulates DNA accessibility based on nucleosome density in vitro and in vivo.