Geeta J. Narlikar

Preferential formation of NUP98::KDM5A condensates at specific H3K4me3-rich loci drives leukemogenic gene expression

This study shows NUP98::KDM5A forms condensates preferentially at H3K4me3-rich loci, driving leukemogenic gene expression through chromatin engagement.

ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation

This study reveals that INO80 reorients on a nucleosome upon ATP hydrolysis, enabling DNA translocation through a unique mechanism distinct from other chromatin remodelers.

ATP-dependent remodeling of chromatin condensates uncovers distinct mesoscale effects of two remodelers

The paper investigates how two chromatin remodelers, ACF and RSC, affect chromatin condensation and dynamics, revealing distinct mesoscale effects on chromatin structure and function.

HMGB1 restores a dynamic chromatin environment in the presence of linker histone by deforming nucleosomal DNA

This study shows HMGB1 counteracts linker histone H1 by distorting nucleosomal DNA and contacting H1's C-terminal tail, enabling co-occupancy and dynamic chromatin states.

Satb1 integrates cohesin mediated genome organization and transcriptional regulation during T cell development

This study shows Satb1 interacts with cohesin and CTCF to regulate chromatin organization and gene expression during T cell development.

Chromatin mimicry by human JC virus

This study shows JC polyomavirus uses epigenetic mimicry to alter nuclear architecture, enabling viral replication and persistence.

Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells

This study shows that satellite repeat transcripts in mouse ESCs drive heterochromatin condensates, which are crucial for chromosome stability and nuclear organization.

Single-fiber nucleosome density shapes the regulatory output of a mammalian chromatin remodeling enzyme

This study uses a single-molecule platform to show that SNF2h, a chromatin remodeler, regulates DNA accessibility based on nucleosome density in vitro and in vivo.

Massively multiplex single-molecule oligonucleosome footprinting

The paper introduces a single-molecule sequencing method to measure nucleosome positions on chromatin fibers and reveals heterogeneous patterns of oligonucleosome occupancy across epigenomic domains.

ATP hydrolysis by the SNF2 domain of the ultraspecific maintenance methylase Dnmt5 drives recognition and modification of hemimethylated DNA

The paper shows that ATP hydrolysis by the SNF2 domain of Dnmt5 is coupled to DNA methylation, enhancing substrate specificity through base-flipping mechanisms.

Evolutionary persistence of DNA methylation for millions of years after ancient loss of a de novo methyltransferase

The paper shows that DNA methylation persists in Cryptococcus neoformans despite the loss of a de novo methyltransferase, with methylation patterns maintained through replication and natural selection.