Coxsackievirus B Escapes Antiviral CD8⁺ T Cells but Triggers Robust CD4⁺ Memory Responses
Orlando Burgos Morales, Federica Vecchio, Fatoumata Samassa, Margot Petit, Zhicheng Zhou, Barbara Brandao, Alexia Carré, Annalisa Nicastri, Valeriia Dotsenko, Chloe M. Shepherd, Keijo M. Viiri, Robert Parker, Amelia K. Linnemann, Sylvaine You, Malin Flodström‐Tullberg, , Roberto Mallone
This study shows that Coxsackievirus B3 evades CD8+ T-cell immunity by downregulating HLA Class I and viral peptide presentation, while inducing robust CD4+ T-cell responses and memory formation.
Science Advances · Jun 19, 2026Peer-reviewedImmunology