Author

Spencer C. Knight

University of LiègeORCID 0000-0002-1909-1358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 3 Assay:GWAS summary statistics· 3 Organism:human· 3 Approach:statistical model· 3

Frequent Co-Authors

Ahna Reza Girshick· 3 shared Asher K. Haug-Baltzell· 3 shared Harendra GuturuiD· 3 shared Marie V. CoignetiD· 3 shared Raghavendran ParthaiD· 3 shared Shannon McCurdyiD· 3 shared Brooke L. RheadiD· 2 shared Catherine A. Ball· 2 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Ahna Reza Girshick

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3 papers

Recent·Most cited

Mapping the human genetic architecture of COVID-19: an update

COVID-19 Host Genetics Initiative, Leadership, Gita A. Pathak, Juha M Karjalainen, Christine R. Stevens, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Writing group, Writing group lead, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Analysis group, Manuscript analyses team lead, , David Morrison

This study updates the genetic architecture of COVID-19 by adding 11 new genome-wide significant loci through a large GWAS meta-analysis.

Nature · Aug 3, 2022Peer-reviewedGenetic & Genomic Medicine

Novel COVID-19 phenotype definitions reveal phenotypically distinct patterns of genetic association and protective effects

Genevieve H. L. Roberts, Raghavendran Partha, Brooke L. Rhead, Spencer C. Knight, Danny S. Park, Marie V. Coignet, Miao Zhang, Nathan Berkowitz, David A. Turissini, Michael Gaddis, Shannon McCurdy, Milos Pavlovic, Luong Ruiz, Chodon Sass, AncestryDNA Science Team, , Kristin A. Rand

The paper defines novel COVID-19 phenotypes and shows they reveal distinct genetic associations and protective effects compared to traditional definitions.

Nature Genetics · Apr 1, 2022Peer-reviewedGenetic & Genomic Medicine

Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease

Julie E. Horowitz, Jack A. Kosmicki, Amy Damask, Deepika Sharma, Genevieve H. L. Roberts, Anne E. Justice, Nilanjana Banerjee, Marie V. Coignet, Ashish Yadav, Joseph B. Leader, Anthony Marcketta, Danny S. Park, Rouel Lanche, Evan K. Maxwell, Spencer C. Knight, , Arden Moscati

The paper identifies a rare variant that lowers ACE2 expression and reduces COVID-19 risk, and develops a genetic risk score predicting severe disease.

Nature Genetics · Mar 3, 2022Peer-reviewedGenetic & Genomic Medicine