Raghavendran Partha

ERC 2.0 - evolutionary rate covariation update provides more powerful inference of functional interactions across large phylogenies

ERC2.0 improves functional interaction prediction across large phylogenies by enhancing algorithm speed, normalization, and statistical power.

Evolutionary rate covariation is pervasive between glycosylation pathways and points to potential disease modifiers

The paper identifies potential genetic modifiers of Congenital Disorders of Glycosylation (CDG) using evolutionary rate covariation analysis across glycosylation pathways and other biological processes.

Mapping the human genetic architecture of COVID-19: an update

This study updates the genetic architecture of COVID-19 by adding 11 new genome-wide significant loci through a large GWAS meta-analysis.

Novel COVID-19 phenotype definitions reveal phenotypically distinct patterns of genetic association and protective effects

The paper defines novel COVID-19 phenotypes and shows they reveal distinct genetic associations and protective effects compared to traditional definitions.

Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease

The paper identifies a rare variant that lowers ACE2 expression and reduces COVID-19 risk, and develops a genetic risk score predicting severe disease.

A Drosophila natural variation screen identifies NKCC1 as a substrate of NGLY1 deglycosylation and a modifier of NGLY1 deficiency