Liming Pei

The paper presents scMOCHA, a tool to analyze mtDNA heteroplasmy from scRNA-seq data, revealing cell type-specific mtDNA variants and disease mechanisms in hematopoietic cells.

This study uses multimodal imaging and transcriptomics to show increased reactive oxygen species activity in myocardial tissue and systemic organs after myocardial infarction, with associated gene expression changes.

The paper uses activity-based proteomics to identify Secernin-3 as a functional target involved in thermal nociception using phenelzine-based probes.