Deborah K. Morrison

This study analyzes the free energy and flexibility of autoinhibited human BRAF using molecular dynamics simulations based on a cryo-EM model to understand its activation mechanism.

This study develops an in vitro BRAF activation assay to elucidate molecular mechanisms of BRAF disassembly and identifies RAS binding as critical for activation.

This study shows that specific KRAS mutations, like A59E, cooperate with other genetic alterations in CRC and affect response to EGFR inhibitors.