Author

Fikret Aydin

Lawrence Livermore National LaboratoryORCID 0000-0003-3237-8043Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Deborah K. MorrisoniD· 2 shared Dwight V. NisselyiD· 2 shared Felice C. LightstoneiD· 2 shared Frederick H. StreitziD· 2 shared Helgi I. IngólfssoniD· 2 shared Jeremy O. B. TempkiniD· 2 shared Timothy S. CarpenteriD· 2 shared Xiao‐Hua ZhangiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Deborah K. MorrisonORCID

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Author profile →

2 papers

Recent·Most cited

Free energy and flexibility analysis of autoinhibited human BRAF

Jeremy O. B. Tempkin, Fikret Aydin, Sebnem G. Essiz, Yue Yang, Timothy S. Carpenter, David E. Durrant, Deborah K. Morrison, Helgi I. Ingólfsson, Frederick H. Streitz, Dwight V. Nissely, Felice C. Lightstone, Xiao‐Hua Zhang

This study analyzes the free energy and flexibility of autoinhibited human BRAF using molecular dynamics simulations based on a cryo-EM model to understand its activation mechanism.

Journal of Chemical Information and Modeling · Apr 21, 2026Peer-reviewedBiophysics

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving the Disassembly of the Autoinhibited BRAF State

Daniel A. Ritt, David Durrant, Matthew R. Drew, Suzanne I. Sandin, Juliana A. Martinez Fiesco, Xiao‐Hua Zhang, Fikret Aydin, Timothy S. Carpenter, Grace M. Scheidemantle, Robert A. D’Ippolito, Alexandria L. Sohn, Caroline J. DeHart, Rebika Shrestha, Kelly Snead, Jenna Hull, , Deborah K. Morrison

This study develops an in vitro BRAF activation assay to elucidate molecular mechanisms of BRAF disassembly and identifies RAS binding as critical for activation.

Proceedings of the National Academy of Sciences · Sep 15, 2025Peer-reviewedBiochemistry