Johann Sebastian De Bono

ProMPt is a syngeneic mouse platform modeling prostate cancer heterogeneity, revealing MYC's role in progression and showing that MAPK inhibition plus translation blockade synergistically suppresses castration-resistant tumors.

This study identifies CBP/p300 as critical for DNA repair in prostate cancer and shows that targeting it enhances therapeutic response.

This study shows targeting a STING agonist to perivascular macrophages in ADT-treated prostate tumors delays castration resistance prostate cancer onset.

This study investigates Thio-2's mechanism of action in inhibiting AR signaling in CRPC, showing it acts independently of BAG-1 isoforms and with potential AR NTD binding.

This study identifies germline genetic variants influencing somatic mutation patterns in 2,642 cancer genomes across 39 cancer types.