Anna Allué‐Guardia

A single PA-X mutation in bovine-origin H5N1 influenza virus reduces pathogenicity in mice

This paper identifies a PA-X mutation in H5N1 influenza virus that reduces pathogenicity in mice by modulating immune responses rather than polymerase activity.

Replication Kinetics, Pathogenicity and Virus-induced Cellular Responses of Cattle-origin Influenza A(H5N1) Isolates from Texas, United States

This study compares replication and pathogenicity of cattle-origin H5N1 influenza viruses in mammals and birds, finding higher replication efficiency and pathogenicity in human-adapted isolates.

Impact of the elderly lung mucosa on Mycobacterium tuberculosis metabolic adaptation during infection of alveolar epithelial cells

This study shows that elderly lung mucosa alters Mycobacterium tuberculosis gene expression, enhancing its metabolic adaptation and survival in alveolar epithelial cells.

Host- and age-dependent transcriptional changes in Mycobacterium tuberculosis cell envelope biosynthesis genes after exposure to human alveolar lining fluid

This study shows that Mycobacterium tuberculosis alters its cell envelope gene expression in response to human alveolar lining fluid, with differences observed between young and elderly donors.

The aging lung mucosa: A proteomics study

This study identifies neutrophils in elderly lungs as contributors to a dysregulated environment, providing a proteomic baseline for future research on respiratory infection susceptibility.