Vinay Shivanna

This study identifies critical residues in SARS-CoV-2 Nsp1 that determine viral pathogenicity in mice by reducing replication and immune response severity.

This study compares the pathogenicity and transmissibility of two H5N1 genotypes in ferrets, finding B3.13 is more pathogenic and transmissible than D1.1, while D1.1 acquires adaptive mutations rapidly.

This paper develops a multivalent live-attenuated influenza vaccine that provides broad protection against multiple H5N1 clades by incorporating HA and NA from representative clades, showing robust immune responses and protection in mice.

This study shows that an attenuated Mycobacterium tuberculosis vaccine induces bronchus-associated lymphoid tissue (iBALT) and protects against heterologous TB challenge in macaques.

This paper identifies a PA-X mutation in H5N1 influenza virus that reduces pathogenicity in mice by modulating immune responses rather than polymerase activity.

This study evaluates a modified BCG vaccine overexpressing cyclic di-AMP, showing improved protection against TB in rhesus macaques.

This paper develops a live attenuated vaccine candidate, LPhTXdNS1, against H5N1 influenza viruses and shows it is safe, immunogenic, and protective in mice.

This study identifies amino acid changes in the PB2 protein of H5N1 HPAIV that enhance replication and pathogenicity in human cells and mice.

This study compares replication and pathogenicity of cattle-origin H5N1 influenza viruses in mammals and birds, finding higher replication efficiency and pathogenicity in human-adapted isolates.