Author

Jesse Boumelha

Icahn School of Medicine at Mount SinaiORCID 0000-0001-7635-2537Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Miriam MéradiD· 3 shared Darwin D’souzaiD· 2 shared Edgar Gonzalez‐KozlovaiD· 2 shared Emir Radkevich· 2 shared Guillaume MestralletiD· 2 shared Nina BhardwajiD· 2 shared Pauline HamoniD· 2 shared Raphaël MattiuziD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Miriam MéradORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer

Raphaël Mattiuz, Jesse Boumelha, Emmanouil Aerakis, Jessica Le Bérichel, Pauline Hamon, László Halász, Abishek Balachandra Vaidya, Brian Y. Soong, Emir Radkevich, Hye Mi Kim, Matthew D. Park, Romain Donné, Leanna Troncoso, Rachel A. Kaplan, Clotilde Hennequin, , Miriam Mérad

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

Science · Jul 16, 2026Peer-reviewedImmunology

Oncogenic RAS activity is linked to immune priming and adenosine-driven immune evasion in lung adenocarcinoma

Sophie de Carné Trécesson, Philip East, Claire E. Pillsbury, Mariana Silva dos Santos, Hongui Cha, Emma Colliver, Tegan Gilmore, Sareena Rana, Chris Moore, Scott Lighterness, Deborah R. Caswell, Jesse Boumelha, Mona Tomaschko, Romain Baer, Jim E. Eyles, , Julian Downward

This study links oncogenic RAS activity to immune priming and adenosine-driven immune evasion in lung adenocarcinoma, showing both pro-immunogenic and immunosuppressive effects.

bioRxiv · Nov 25, 2025 · PreprintCancer Biology

Targeting neoantigens conserved across organs and species overcomes tumor immune escape

Guillaume Mestrallet, Ross W. Ward, Matthew Brown, Jesse Boumelha, Frederika Rentzeperis, Natalie Vaninov, Miriam Saffern, Ezekiel Olumuyide, Prerna Suri, Sreekumar Balan, Leandra Velazquez, Aparna Ananthanarayanan, Zhihong Chen, Aimee L. Lucas, Miriam Mérad, , Nina Bhardwaj

This study identifies conserved neoantigens across species and tissues that elicit strong immune responses and suppress tumor growth through vaccination.

bioRxiv · Sep 25, 2025 · PreprintImmunology

Informing biologically relevant signal from spatial transcriptomic data

Emir Radkevich, Darwin D’souza, Raphaël Mattiuz, Raphaël Merand, Rachel Chen, Jarod Morgenroth-Rebin, Krista Angeliadis, Daniella Nelson, Anis Kara, Travis Dawson, Igor De Souza, Kai Nie, Pauline Hamon, Samarth Hegde, Jesse Boumelha, , Vladimir Roudko

The paper benchmarks deconvolution tools for spatial transcriptomic data and introduces a novel pipeline to analyze tissue microenvironment dynamics.

bioRxiv · Sep 9, 2024 · PreprintBioinformatics