Shreya Nirmalan

Lifestyle-mediated shifts in the gut microbiome and host genetics modulate gene expression in intestinal organoids

The paper investigates how lifestyle-associated microbiome shifts and host genetics influence gene expression in intestinal organoids, identifying microbiome-dependent allele-specific expression effects.

Host genotypes interact with microbial communities to modulate gene expression in the human intestine

The paper identifies gene-microbe interactions that modulate host gene expression in the human intestine and links them to IBD risk.

Host transcriptional responses to gut microbiome variation arising from urbanism

The paper compares host transcriptional responses to urban and rural gut microbiomes, finding urban microbiomes affect innate immune pathways and high-diversity microbiomes trigger stronger host responses.

Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma

The paper identifies gene expression changes in immune cells during pubertal development in children with asthma, showing shifts in immunity and correlations with asthma-related gene expression.