Adnan Alazizi

The paper investigates how lifestyle-associated microbiome shifts and host genetics influence gene expression in intestinal organoids, identifying microbiome-dependent allele-specific expression effects.

The paper investigates host-microbiome metabolic interactions in colorectal cancer using computational and experimental methods, revealing how tumor metabolic changes support pathogenic microbes.

The paper compares host transcriptional responses to urban and rural gut microbiomes, finding urban microbiomes affect innate immune pathways and high-diversity microbiomes trigger stronger host responses.

The paper identifies opposing gene regulatory mechanisms in CD4+ T cells and monocytes associated with psychological stress and social support in African American adults using scRNA-seq and scATAC-seq.

The paper uses scATAC-seq to analyze chromatin accessibility and gene expression dynamics in immune cells from asthmatic children, identifying eQTLs and their regulatory roles in asthma risk.

The paper identifies genetic variants that modify gene expression in response to caffeine in vascular endothelial cells and shows their potential role in cardiovascular disease.

The paper uses single-cell RNA-seq to study how genetic variants influence the transcriptional response to glucocorticoids and immune stimuli in children, identifying treatment-specific gene regulation.

The paper analyzes single nucleus transcriptomics data from opioid overdose cases and controls to show widespread glial activation and changes in gene expression related to substance use traits.

The paper identifies gene expression changes in immune cells during pubertal development in children with asthma, showing shifts in immunity and correlations with asthma-related gene expression.

The paper identifies 138 genes differentially expressed in blood immune cells associated with poverty, enriched in wound healing and coagulation, and linked to hypertension.

The paper investigates how interspecies variation in hominid gut microbiota affects host gene regulation in colonic epithelial cells, finding species-specific gene responses linked to inflammatory diseases.

The paper identifies 174 asthma-associated genes regulated by psychosocial factors and 349 gene-environment interactions using RNA-sequencing and machine learning in children with asthma.

The paper identifies gene-environment interactions in gene regulation across cell types and treatments, revealing many genes missed by GTEx.

The paper investigates ACE2 and TMPRSS2 expression in human placenta across pregnancy stages and finds negligible co-expression, suggesting SARS-CoV-2 is unlikely to infect placenta via canonical entry mediators.

The paper investigates gene-environment interactions in coronary artery disease by analyzing RNA-seq and ATAC-seq data from endothelial cells exposed to environmental factors, finding links between environmental responses and CAD risk.

The paper shows gut microbiota influences host gene regulation, identifying specific taxa and genes, and demonstrates microbiome manipulation can alter gene expression profiles.

The paper shows environmental changes cause widespread shifts in RNA processing across multiple cell types and identifies trans factor regulation of these changes.

This study identifies gene expression changes and host SNPs influenced by the gut microbiome in human cells, linking them to microbiome-related diseases.