Julong Wei

Host genotypes interact with microbial communities to modulate gene expression in the human intestine

The paper identifies gene-microbe interactions that modulate host gene expression in the human intestine and links them to IBD risk.

Fine-mapping methods for complex traits: essential adaptations for samples of related individuals

This paper introduces Bayesian fine-mapping methods adapted for related individuals, showing improved accuracy in pig data compared to existing tools.

Psychological stress and social support are associated with opposing single-cell pro-inflammatory gene regulatory mechanisms in adults

The paper identifies opposing gene regulatory mechanisms in CD4+ T cells and monocytes associated with psychological stress and social support in African American adults using scRNA-seq and scATAC-seq.

Functional characterization of eQTLs and asthma risk loci with scATAC-seq across immune cell types and contexts

The paper uses scATAC-seq to analyze chromatin accessibility and gene expression dynamics in immune cells from asthmatic children, identifying eQTLs and their regulatory roles in asthma risk.

Characterization of caffeine response regulatory variants in vascular endothelial cells

The paper identifies genetic variants that modify gene expression in response to caffeine in vascular endothelial cells and shows their potential role in cardiovascular disease.

Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single cell resolution

The paper uses single-cell RNA-seq to study how genetic variants influence the transcriptional response to glucocorticoids and immune stimuli in children, identifying treatment-specific gene regulation.

Single Nucleus Transcriptomics Reveals Pervasive Glial Activation in Opioid Overdose Cases

The paper analyzes single nucleus transcriptomics data from opioid overdose cases and controls to show widespread glial activation and changes in gene expression related to substance use traits.

Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma

The paper identifies gene expression changes in immune cells during pubertal development in children with asthma, showing shifts in immunity and correlations with asthma-related gene expression.

Extended Application of Genomic Selection to Screen Multi-Omics Data for Prognostic Signatures of Prostate Cancer

The paper applies genomic selection methods to multi-omics data to develop prognostic signatures for prostate cancer, showing improved predictability and computational efficiency.

Inference of Chromosome-length Haplotypes Using Genomic Data of Three to Five Single Gametes

Hapi infers chromosome-length haplotypes from 3-5 gametes, outperforming existing methods in accuracy, reliability, and cost efficiency.

Efficient Multivariate Analysis Algorithms for Longitudinal Genome-wide Association Studies

The paper develops efficient multivariate association algorithms for longitudinal GWAS, improving statistical power and computational speed for analyzing large-scale longitudinal data.

GDCRNATools: an R/Bioconductor package for integrative analysis of lncRNA, miRNA, and mRNA data in GDC

GDCRNATools provides an R/Bioconductor package for analyzing lncRNA, miRNA, and mRNA data from the GDC to study ceRNA regulatory networks in cancers.

Optimizing Trait Predictability in Hybrid Rice Using Superior Prediction Models and Selective Omic Datasets

The paper evaluates prediction strategies for hybrid rice traits using various omic datasets and methods, finding genomic-metabolomic combinations and BLUP as most effective.