Simon J. Moore

A liquid handling platform for standardised quantification of cell-free enzymatic activity encoded by antimicrobial resistance genes

The paper develops a semi-automated workflow using cell-free gene expression systems to measure enzymatic activity of antimicrobial resistance genes, showing no difference in results between automated and manual methods.

Biosynthesis of Arcyriaflavin F from Streptomyces venezuelae ATCC 10712

This paper reports a new indolocarbazole biosynthetic pathway in Streptomyces venezuelae and identifies a regioselective C-5 hydroxylating enzyme.

A GenoChemetic strategy for derivatization of the violacein natural product scaffold

The paper demonstrates a method to generate diverse halogenated and derivatized analogues of the natural product violacein using synthetic biology and chemistry.

A curcumin direct protein (DiPro) biosensor for cell-free prototyping

The paper develops a curcumin-based DiPro biosensor for cell-free biosynthesis, achieving an 80-fold increase in fluorescence through optimized reaction parameters.

A Streptomyces venezuelae Cell-Free Toolkit for Synthetic Biology

The paper presents an improved Streptomyces venezuelae cell-free TX-TL system with higher protein yields and reduced batch variation, enabling synthetic biology applications.

A cell-free synthetic biochemistry platform for raspberry ketone production

This paper describes a cell-free synthetic biochemistry platform that achieves high yield raspberry ketone production through an optimised enzymatic pathway.