Hung‐En Lai

DiscERN is a tool for discovering evolutionarily related natural products by analyzing genomes, validated by isolating a new antibiotic.

This paper reports a new indolocarbazole biosynthetic pathway in Streptomyces venezuelae and identifies a regioselective C-5 hydroxylating enzyme.

The paper demonstrates a method to generate diverse halogenated and derivatized analogues of the natural product violacein using synthetic biology and chemistry.

The paper presents an improved Streptomyces venezuelae cell-free TX-TL system with higher protein yields and reduced batch variation, enabling synthetic biology applications.

This paper demonstrates the use of a bacterial biosynthesis platform to produce and screen violacein derivatives for antimalarial activity against Plasmodium falciparum.

This paper develops a low-cost agglutination assay using E. coli-displayed nanobodies for detecting biomarkers with high selectivity and low detection limits, suitable for point-of-care testing.