Franklin S. Caval-Holme

Divergence of Melanopsin's Intrinsic Properties and Downstream Actions

The paper shows that melanopsin's downstream effects can diverge from its intrinsic wavelength sensitivity due to persistent activity and adaptation.

Feature Selectivity for Circadian Regulation within Melanopsin Photoreceptors

The paper identifies feature selectivity in M1 melanopsin photoreceptors for circadian regulation, showing their role in encoding light features that synchronize with the day-night cycle.

Adapting a two-photon scanning microscope for simultaneous single-photon imaging of an infrared dopamine sensor

The paper adapts a two-photon microscope to detect both visible and near-infrared fluorescence, enabling simultaneous dopamine and calcium imaging in the retina.

Molecular and spatial analysis of ganglion cells on retinal flatmounts: diversity, topography, and perivascularity

The paper maps the spatial distribution of retinal ganglion cell types and identifies perivascular RGCs that show neuroprotection after optic nerve injury.

Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex

This study shows that reducing Raptor, a component of mTORC1, improves TSC-related brain phenotypes in mouse models, suggesting it as a potential therapeutic target.

The Retinal Basis of Photoaversion in Neonatal Mice

This study identifies M1 ipRGCs as the primary driver of photoaversion in neonatal mice by showing their unique photosensitivity and behavioral relevance.