Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth
Anna Maekiniemi, Philipp Savakis, Kelly van Rossum, Jacky L. Snoep, Markus Seiler, David D. van Niekerk, Kathi Zarnack, Robert H. Singer, Evelina Tutucci
The paper shows that CLB2 mRNA localization to the bud via the She2/She3 complex enhances translation, linking cell growth to cell cycle progression through a ZIP-code element in the coding sequence.
Nature Communications · Nov 26, 2025Peer-reviewedMolecular Biology