Leyma Wardak

An early mTOR-dependent window during human T cell activation programs T cell state

This study identifies an early mTOR-dependent window during human T cell activation that programs cytotoxic fate or memory-like state, with transient inhibition promoting memory while preserving effector functions.

Single molecule imaging of transcription dynamics, RNA localization and fate in T cells

This study uses single-molecule FISH to analyze cytokine mRNA dynamics in T cells, revealing transcriptional heterogeneity and post-transcriptional regulation by HuR.

γδ T cells are the prime anti-tumoral T cells in pediatric neuroblastoma

The paper shows that γδ T cells, not β T cells, are the main anti-tumoral immune cells in pediatric neuroblastoma after chemotherapy.

Proximity labeling reveals ZFP36L1 as a central hub for post-transcriptional regulation networks in T cells

The paper maps the ZFP36L1 interactome in human T cells using proximity labeling, revealing its role in post-transcriptional regulation and protein expression.