Michael Neil Shadlen

Neural correlates of ketamine-induced dilation of temporal expectation

This study shows that ketamine alters time perception and neural activity in the parietal area LIP in macaques, affecting both single-neuron and population-level dynamics.

Behavioral demands organize a decision process into distinct yet coordinated neural representations in parietal cortex

The paper investigates how behavioral demands shape distinct yet coordinated neural representations in parietal cortex during decision-making.

Decoupling Choice from Motor Response Reduces Choice-History Effects

The paper shows that decoupling perceptual choices from motor responses reduces choice-history effects in non-human primates.

Behavioral Signatures of Post-Decisional Attention in Preferential Choice

This study reanalyzes food-choice datasets to test models of attention's role in decision-making, finding no support for multiplicative effects and proposing an alternative model that better explains gaze behavior.

Transfer of graded information through gated receptivity to widely broadcast signals

The paper presents a computational model explaining how analog-valued decision information is transferred between neuronal populations through dynamic gating during eye movements.

ALM enables contextual decision-making via dynamic reconfiguration of local circuits

This study shows that ALM reconfigures local circuits to route sensory input to motor output based on context, using contingency neurons that encode both context and choice.

Sequential sampling from memory underlies perceptual decisions unyoked from actions

The paper shows that humans delay perceptual decisions until relevant choices are presented, using a bounded diffusion model to explain decision-making based on stored sensory information.

Motor cortex flexibly deploys a high-dimensional repertoire of subskills

This study shows that motor cortex activity is high-dimensional and flexible, with distinct neural dynamics for different subskills during a force-tracking task.

Incorporation of a cost of deliberation time in perceptual decision making

The paper tests how time costs affect decision-making by manipulating time pressure in a perceptual task, finding that participants made faster but less accurate decisions.

Large-scale high-density brain-wide neural recording in nonhuman primates

The paper introduces Neuropixels 1.0-NHP, a high-density electrode array for large-scale neural recording in nonhuman primates, enabling recording from over 3000 single neurons.

Population Representation of the Confidence in a Decision in the Parietal Cortex

The paper shows that neurons in the lateral intraparietal area encode confidence in decision accuracy through population-level variability, despite individual neurons showing no correlation with accuracy.

DREDge: robust motion correction for high-density extracellular recordings across species

DREDge improves motion correction in high-density extracellular recordings across species, enhancing reliability and reducing errors in electrophysiological data.

The geometry of the neural state space of decisions

The paper analyzes neural population activity during decision-making and finds that decision trajectories lie on a curved 2D manifold, with distinct dynamics for slow and fast decisions.

Value construction through sequential sampling explains serial dependencies in decision making

The paper shows that subjective values change during decision-making tasks and introduces a model to detect these changes in choices and neural signals.

Direct observation of the neural computations underlying a single decision

The paper directly observes the neural computations underlying a single decision by analyzing population activity in monkey lateral intraparietal cortex during motion direction decisions.

Transient oscillations of neural firing rate associated with routing of evidence in a perceptual decision

This study shows that transient neural firing rate oscillations in parietal cortex occur during the routing of evidence in perceptual decisions, but not during information transmission.

A neural mechanism for terminating decisions

This study identifies a neural mechanism in the primate superior colliculus that terminates decision-making by applying a threshold to lateral intraparietal cortex activity.

Judging the difficulty of perceptual decisions

The paper examines how people judge the difficulty of perceptual tasks and finds that decisions are based on accumulated evidence differences rather than confidence.

Flexible neural control of motor units

This study shows that motor units are flexibly controlled by the cortex, challenging the traditional view of common drive and rigid recruitment.

Deficits in decision-making induced by parietal cortex inactivation are compensated at two time scales

This study shows that inactivating the lateral intraparietal area in monkeys leads to decision-making deficits that are compensated for quickly within sessions and more slowly across sessions.

Sequential sampling from memory underlies action selection during abstract decision making

This study shows that monkeys delay decision formation until motor actions are available, with neurons retrieving evidence from short-term memory during abstract decisions.

Decision formation in parietal cortex transcends a fixed frame of reference

The paper shows that decision formation in parietal cortex maintains continuity across actions by ensembles of neurons, transcending a fixed frame of reference.

Multiple decisions about one object involve parallel sensory acquisition but time-multiplexed evidence incorporation

The paper investigates how the brain processes two decisions about one object, finding parallel sensory acquisition but time-multiplexed evidence incorporation.

Low dimensional dynamics for working memory and time encoding

The paper analyzes neural activity in non-human primates during time delays to understand working memory and time encoding mechanisms, finding that time can be decoded with high precision and neural trajectories are low dimensional.

Differentiating between integration and non-integration strategies in perceptual decision making

The paper investigates strategies in perceptual decision making, distinguishing between integration and non-integration models and finding that non-integration strategies can mimic integration.

Context-dependent decision making in a premotor circuit

The paper investigates how context influences olfactory decision-making by examining the role of the premotor area ALM in a delayed match-to-sample task.

Counterfactual reasoning underlies the learning of priors in decision making

Participants learned base rates from decision-making without feedback by updating their beliefs using counterfactual confidence representations, improving accuracy and confidence.

Focal optogenetic suppression in macaque area MT biases direction discrimination and choice confidence, but only transiently

This study uses optogenetic suppression in macaque area MT to examine its effects on direction discrimination and choice confidence, finding transient behavioral impacts.

Comparison of decision-related signals in sensory and motor preparatory responses of neurons in Area LIP

The paper compares sensory and motor preparatory responses in LIP neurons during decision-making tasks, finding that motor responses track evidence accumulation while sensory responses do not.

Value-based decisions involve sequential sampling from memory

The paper shows that decision-making between similar options involves memory-based evidence construction, with hippocampal activity linked to deliberation time and value formation.