Quercetin activates the SIRT6-Nrf2 axis during oxidative stress, modulating ageing-associated markers in healthy men
Ciara Gallardo Juan, Nina Šimunić Briški, Fabiana Volpe-Zanutto, Kyle Matchett, Gareth W. Davison
This study investigates quercetin's effects on oxidative stress and DNA damage responses in healthy men during exercise, showing increased nuclear localization and gene expression related to DNA repair and antioxidant pathways.
medRxiv · Oct 31, 2025 · PreprintGenetic & Genomic Medicine