This study identifies tissue-specific sex-biased DNA methylation changes across the lifespan, showing that age-related methylation changes are widespread but sex effects are rare and tissue-specific.

bioRxiv · Apr 21, 2026 · PreprintGenetics

DNA Methylation Ageing Atlas Across 17 Human Tissues

Macsue Jacques, Kirsten Seale, Sarah Amandine Caroline Voisin, Anna Lysenko, Robin Grolaux, Bernadette Jones, Séverine Lamon, Itamar Levinger, Carlie Bauer, Adam Philip Sharples, Aino Heikkinen, Elina Sillanpää, Miina Ollikainen, Cassandra Smith, James R. Broatch, , Nir Eynon

The paper creates a DNA methylation aging atlas across 17 human tissues, identifying conserved and tissue-specific aging signatures and potential therapeutic targets.

bioRxiv · Jul 21, 2025 · PreprintBioinformatics

A comprehensive map of the ageing blood methylome

Kirsten Seale, Andrew Erich Teschendorff, Alex P. Reiner, Sarah Amandine Caroline Voisin, Nir Eynon

This study identifies 48% differentially methylated positions and 37% variably methylated positions in blood methylomes across aging, revealing their roles in entropy and epigenetic clocks.

bioRxiv · Dec 20, 2023 · PreprintMolecular Biology

A meta-analysis of immune cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes

Qi Luo, Varun Bhamidipati Dwaraka, Qingwen Chen, Huige Tong, Tianyu Zhu, Kirsten Seale, Joseph M. Raffaele, Shijie Zheng, Tavis L. Mendez, Yulu Chen, Natàlia Carreras-Gallo, Sofina Begum, Kevin M. Mendez, Sarah Amandine Caroline Voisin, Nir Eynon, , Andrew Erich Teschendorff

This paper uses DNA methylation data to analyze immune cell fractions across 25,629 blood samples, identifying associations with age, sex, health outcomes, and lifestyle factors.

Genome Medicine · Jul 31, 2023Peer-reviewedBioinformatics

Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

Sarah Amandine Caroline Voisin, Kirsten Seale, Macsue Jacques, Shanie Landen, Nicholas R. Harvey, Larisa Margaret Haupt, Lyn Robyn Griffiths, Kevin J. Ashton, Vernon G. Coffey, Jamie‐Lee M. Thompson, Thomas M. Doering, Maléne E. Lindholm, Colum P. Walsh, Gareth W. Davison, Rachelle E Irwin, , Nir Eynon

This study shows exercise training reduces epigenetic and transcriptomic aging in human skeletal muscle, while muscle disuse accelerates transcriptomic aging.

Aging Cell · May 2, 2023Peer-reviewedMolecular Biology

Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism

Shanie Landen, Macsue Jacques, Danielle Hiam, Javier Alvarez‐Romero, Nicholas R. Harvey, Larisa Margaret Haupt, Lyn Robyn Griffiths, Kevin J. Ashton, Séverine Lamon, Sarah Amandine Caroline Voisin, Nir Eynon

The paper integrates skeletal muscle methylome and transcriptome data across three cohorts to identify sex differences in DNA methylation and gene expression, revealing functional links between epigenetic and transcriptional sex biases.

Clinical Epigenetics · Dec 1, 2021Peer-reviewedGenomics

Meta-analysis of genome-wide DNA methylation and integrative OMICs in human skeletal muscle.

Sarah Amandine Caroline Voisin, Macsue Jacques, Shanie Landen, Nicholas R. Harvey, Larisa Margaret Haupt, Lyn Robyn Griffiths, Sofiya Gancheva, Meriem Ouni, Markus Jähnert, Kevin J. Ashton, VG Coffey, Jamie‐Lee M. Thompson, Thomas M. Doering, Anne Gabory, Claudine Junien, , Nir Eynon

The paper identifies age-related DNA methylation changes in human skeletal muscle through a meta-analysis and integrates these with transcriptomic and proteomic data, revealing enriched age-related gene expression patterns.

bioRxiv · Sep 28, 2020 · PreprintGenetics

Identification of novel mitochondrial and mitochondrial related genetic loci associated with exercise response in the Gene SMART study

Nicholas R. Harvey, Sarah Amandine Caroline Voisin, Rod A. Lea, Xu Yan, Miles C. Benton, Ioannis D. Papadimitriou, Macsue Jacques, Larisa Margaret Haupt, Kevin J. Ashton, Nir Eynon, Lyn Robyn Griffiths

The paper identifies nine nuclear-encoded SNPs associated with exercise response in the Gene SMART cohort using whole-mitochondrial genome sequencing and composite trait analysis.

bioRxiv · Feb 20, 2020 · PreprintGenetics

An epigenetic clock for human skeletal muscle

Sarah Amandine Caroline Voisin, Nicholas R. Harvey, Larisa Margaret Haupt, Lyn Robyn Griffiths, Kevin J. Ashton, Vernon G. Coffey, Thomas M. Doering, Jamie‐Lee M. Thompson, Christian Benedict, Jonathan Cedernaes, Maléne E. Lindholm, Jeffrey Mark Craig, DAVID STEPHEN ROWLANDS, Adam Philip Sharples, Steve Horvath, Nir Eynon

The paper develops a muscle-specific epigenetic clock using DNA methylation data from skeletal muscle samples, achieving higher accuracy than a pan-tissue clock.

Journal of Cachexia Sarcopenia and Muscle · Feb 17, 2020Peer-reviewedBioinformatics