Author

Rachelle E Irwin

University of UlsterORCID 0000-0002-6137-1716Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Colum P. WalshiD· 3 shared Adam Philip SharplesiD· 1 shared Aino HeikkineniD· 1 shared Alan Mark O’DohertyiD· 1 shared Avinash ThakuriD· 1 shared Catherine A. Scullion· 1 shared Catherine McBride· 1 shared David A. Magee· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersGenomics

Colum P. WalshORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Molecular BiologyAging CellPeer-reviewedMay 2, 2023

Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

Sarah Amandine Caroline Voisin, Kirsten Seale, Macsue Jacques…·Nir Eynon

This study shows exercise training reduces epigenetic and transcriptomic aging in human skeletal muscle, while muscle disuse accelerates transcriptomic aging.

77 citations

humanDNA methylation

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GenomicsbioRxivPreprintAug 31, 2020

UHRF1 suppresses viral mimicry through both DNA methylation-dependent and -independent mechanisms

Rachelle E Irwin, Catherine A. Scullion, SJ Thursby…·CP Walsh

This study shows UHRF1 suppresses viral mimicry through DNA methylation-dependent and -independent mechanisms by repressing ERV transcription and innate immune response.

2 citations

humanmouse

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GenomicsScientific ReportsPeer-reviewedFeb 6, 2019

The bovine alveolar macrophage DNA methylome is resilient to infection with Mycobacterium bovis

Alan Mark O’Doherty, Kévin Rue-Albrecht, David A. Magee…·David Evan MacHugh

This study examines the DNA methylome of bovine alveolar macrophages infected with Mycobacterium bovis and finds no significant changes in DNA methylation, but identifies genes with intermediate promoter methylation enriched for immune-related functions.

20 citations

bacteria (other)DNA methylation

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