This paper investigates how matrix stiffness and shear stress jointly influence endothelial gene expression and angiogenic activation thresholds using transcriptomics.

bioRxiv · Jul 23, 2026 · PreprintCell Biology

Downregulation of Trpv4 and Klf2 in brain microvessels is associated with the progression of neurovascular dysfunction and cognitive impairment in a model of heart failure with preserved ejection fraction.

Sara M.P. Lambrichts, Laura van der Taelen, Irene Pastor, Peter J. A. Leenders, Nicole J.J.E. Bitsch, Daria Majcher, Denise J. H. P. Hermes, S P Simmonds, Marcel H. M. van Herwijnen, Rick Kamps, Ellen Weltjens, Phyllis J. J. Jessen, H.P. Steinbusch, Floor Arentz, Maximilian Wiesmann, , Sébastien Foulquier

This study shows that reduced Trpv4 and Klf2 in brain microvessels correlates with neurovascular dysfunction and cognitive decline in an HFpEF rat model.

Journal of Cerebral Blood Flow & Metabolism · Jun 12, 2026Peer-reviewedNeuroscience

Simulating flow induced migration in vascular remodelling

Ashkan Tabibian, Siavash Ghaffari, Diego A. Vargas, Hans Van Oosterwyck, Elizabeth A. V. Jones

The paper develops a computational model of endothelial cell migration during vascular remodelling, showing shear stress and cell elongation are key factors.

PLoS Computational Biology · Aug 21, 2020Peer-reviewedDevelopmental Biology