Author

Dhananjay Yellajoshyula

University of MichiganORCID 0000-0002-2031-0917Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Assay:ATAC-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Abigail E. RogersiD· 2 shared Samuel S. PappasiD· 2 shared Vikram G. ShakkottaiiD· 2 shared William T. DaueriD· 2 shared Amrita BasuiD· 1 shared Audrey J. Kim· 1 shared Bingmin Luo· 1 shared Biswa Choudhury· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Abigail E. RogersORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 13, 2026

Lysosomal Glycosaminoglycan Catabolism Regulates Microglial Cell State in the Developing CNS

Keenan T. Hope, Yiwen Zhang, Amrita Basu…·Dhananjay Yellajoshyula

This study shows that lysosomal glycosaminoglycan catabolism in microglia regulates their cell state during CNS development, linking ECM remodeling to microglial identity.

DOI 10.64898/2026.10.11.758365

mousebulk RNA-seq

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NeuroscienceHuman Molecular GeneticsPeer-reviewedOct 20, 2021

A pathogenic DYT-THAP1 dystonia mutation causes hypomyelination and loss of YY1 binding

Dhananjay Yellajoshyula, Abigail E. Rogers, Audrey J. Kim…·William T. Dauer

This study shows that the DYT-THAP1 mutation F81L impairs THAP1 transcriptional activity and disrupts CNS myelination by reducing YY1 DNA binding.

16 citations

humanDNA methylation

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NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedJul 26, 2021

THAP1 Modulates Oligodendrocyte Maturation by Regulating ECM Degradation in Lysosomes

Dhananjay Yellajoshyula, Samuel S. Pappas, Abigail E. Rogers…·William T. Dauer

This study shows THAP1 regulates oligodendrocyte maturation by controlling lysosomal degradation of glycosaminoglycans in OPCs.

17 citations

mousestatistical model

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NeuroscienceHuman Molecular GeneticsPeer-reviewedSep 21, 2020

Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in Spinocerebellar ataxia type 1

Ravi Chopra, David D. Bushart, John P Cooper…·Vikram G. Shakkottai

24 citations

mouseATAC-seq

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