Author

David D. Bushart

University of MichiganORCID 0000-0002-3852-127XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Vikram G. ShakkottaiiD· 4 shared Haoran HuangiD· 3 shared Logan M MorrisoniD· 3 shared Harry T. OrriD· 2 shared Hillary P. HandleriD· 2 shared Luke J. Man· 2 shared Daniel R. ScolesiD· 1 shared Dhananjay YellajoshyulaiD· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Vikram G. ShakkottaiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 23, 2023

Increased intrinsic membrane excitability is associated with hypertrophic olivary degeneration in spinocerebellar ataxia type 1

Logan M Morrison, Haoran Huang, Hillary P. Handler…·Vikram G. Shakkottai

This study identifies increased intrinsic membrane excitability in SCA1-KI mice as a novel mechanism underlying hypertrophic olivary degeneration without inhibitory denervation.

DOI 10.1101/2023.10.23.563657

mouseelectronic health records

𝕏 PostBluesky

NeuroscienceMovement DisordersPeer-reviewedNov 5, 2020

A chlorzoxazone-baclofen combination improves cerebellar impairment in spinocerebellar ataxia type 1

David D. Bushart, Haoran Huang, Luke J. Man…·Vikram G. Shakkottai

The paper identifies optimal chlorzoxazone-baclofen concentrations to improve cerebellar dysfunction in SCA1 without toxicity, proposing a dose escalation trial design.

40 citations

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceHuman Molecular GeneticsPeer-reviewedSep 21, 2020

Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in Spinocerebellar ataxia type 1

Ravi Chopra, David D. Bushart, John P Cooper…·Vikram G. Shakkottai

24 citations

mouseATAC-seq

𝕏 PostBluesky

NeuroscienceStem Cell ResearchPeer-reviewedJul 16, 2019

Antisense oligonucleotide therapy rescues aggresome formation in a novel Spinocerebellar Ataxia type 3 human embryonic stem cell line.

Lauren R. Moore, Laura Keller, David D. Bushart…·Henry Lauris Paulson

This paper describes a novel SCA3 human embryonic stem cell line and shows that antisense oligonucleotides reduce ATXN3 aggregation and prevent aggresome formation.

42 citations

humanexperimental assay

𝕏 PostBluesky