Keenan T. Hope

Lysosomal Glycosaminoglycan Catabolism Regulates Microglial Cell State in the Developing CNS

This study shows that lysosomal glycosaminoglycan catabolism in microglia regulates their cell state during CNS development, linking ECM remodeling to microglial identity.

An output-null signature of inertial load in motor cortex

The paper investigates how motor cortex compensates for inertial load during locomotion in mice, finding that load induces significant cortical dynamics changes independent of motor output.

Microglia drive pockets of neuroinflammation in middle age

The paper shows that microglia in specific brain regions exhibit premature aging-related inflammation in middle age, which may affect nearby neurons.