Xuan Song

The paper shows that breathing at birth triggers CO2 exhalation, which reduces mTOR activity and limits regenerative capacity in CNS neurons and other tissues, but this effect is reversible with CO2 inhalation or Snrk deletion.

The paper evaluates methods for accurately classifying RNA sequencing reads from mixed-species data, finding alignment-dependent and alignment-independent approaches effective across different species ratios.

The paper shows that ATP depletion causes oxidative stress, activates ATM, which phosphorylates NRF1 to enhance mitochondrial function, and that ATM deficiency impairs ATP recovery in energy-demanding cells.