Hei‐Man Chow

This study shows GLP-1R agonism reduces age-related molecular changes in mice, with effects on multiple omic levels and organ-specific rejuvenation.

This study identifies lncMtDloop as a regulator of mitochondrial homeostasis, showing reduced expression in AD and improved pathology with its overexpression.

The paper shows that ATP depletion causes oxidative stress, activates ATM, which phosphorylates NRF1 to enhance mitochondrial function, and that ATM deficiency impairs ATP recovery in energy-demanding cells.