Zhigang He

The paper shows that breathing at birth triggers CO2 exhalation, which reduces mTOR activity and limits regenerative capacity in CNS neurons and other tissues, but this effect is reversible with CO2 inhalation or Snrk deletion.

This study shows that Dsn1 and Ndc80 are essential for postmitotic neuron survival, distinct from their role in synaptogenesis, and identifies domain-specific functions in neuronal viability.

The paper maps conserved cell type signatures in the adult mouse brainstem and spinal cord using multi-omics data, revealing shared and region-specific features.

This study introduces a PET tracer, [18F]3F4AP, to image demyelinated axons in spinal cord injuries and shows its ability to detect injury and monitor changes in animal models and humans.

This study investigates how the secondary somatosensory cortex (S2) modulates mechanical and thermal sensitivity through distinct neural circuits compared to the primary somatosensory cortex (S1).

This study shows that Lphn2's role in axon targeting depends on context-specific G protein coupling and autoproteolytic cleavage.

The paper shows that vibrotactile touch reduces facial pain in mice by altering neural activity in the barrel cortex, integrating tactile and noxious signals.

The paper identifies REST/NRSF as a suppressor of CNS axon regeneration using systems biology approaches and validates its role through genetic manipulations.

The paper identifies four ATF/CEBP transcription factors that drive injury-induced neurodegeneration of retinal ganglion cells and shows their role in glaucoma.

The paper identifies transcriptional programs that enhance survival and axon regeneration of injured retinal ganglion cells using single-cell transcriptomics and computational analysis.

The paper shows that Pink1 mRNA is transported with mitochondria and tethered by SYNJ2BP and SYNJ2 to support local mitophagy in neurons.

The paper shows that reciprocal repulsions between Teneurin-3 and Latrophilin-2 guide the assembly of parallel hippocampal networks during development.

The paper identifies neuroprotective genes in retinal ganglion cells by analyzing their resilience to injury using single-cell RNA-seq and functional assays.

This paper demonstrates that epigenetic reprogramming using OSK genes can reverse age-related and injury-induced vision loss in mice by resetting DNA methylation patterns and promoting axon regeneration.