Gary Yellen

The paper shows that breathing at birth triggers CO2 exhalation, which reduces mTOR activity and limits regenerative capacity in CNS neurons and other tissues, but this effect is reversible with CO2 inhalation or Snrk deletion.

The paper shows that metabolic rates influence developmental speed in mouse and human embryos, with mouse cells having higher metabolic rates and faster segmentation clock periods.

The paper shows that the Na+/K+ pump, not Ca2+ influx, primarily drives glycolysis activation in hippocampal dentate granule cells following neuronal stimulation.

The paper investigates the role of calcium in neuronal energy metabolism, finding that mitochondrial Ca2+ uptake drives NADH buildup in the TCA cycle, while cytosolic glycolytic NADH increases are driven by energy demand, not Ca2+ signaling.