Author

Shane Hegarty

Boston Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Cheng-Hao Chien· 1 shared Daniel Feng· 1 shared Davide SperiiD· 1 shared Evgenii KegelesiD· 1 shared Gary YelleniD· 1 shared Hisashi UmemoriiD· 1 shared James Kiraly· 1 shared Jiawen CheniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Cheng-Hao Chien

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1 paper

Recent·Most cited

The Onset of Breathing at Birth Switches Off Regenerative Capacity

Xuan Song, Xinyi Cai, Shane Hegarty, Davide Speri, Masahiro Yasuda, Ryan Donahue, Joanna Stanicka, Ting Yan, Susu Mao, Sarah Yang, Jiawen Chen, Junjie Zhu, James Kiraly, Cheng-Hao Chien, Evgenii Kegeles, , Zhigang He

The paper shows that breathing at birth triggers CO2 exhalation, which reduces mTOR activity and limits regenerative capacity in CNS neurons and other tissues, but this effect is reversible with CO2 inhalation or Snrk deletion.

bioRxiv · Oct 11, 2026 · PreprintNeuroscience