Author

Xavier Hanoulle

Centre National de la Recherche ScientifiqueORCID 0000-0002-3755-2680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Amandine Flaig· 1 shared Anaïs-Camille Vreulx· 1 shared Andreas PichlmairiD· 1 shared Antonio PirasiD· 1 shared Audrey CouloniD· 1 shared Benjamin Grenier‐BoleyiD· 1 shared Charlotte Bauer· 1 shared Charlotte Delay· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Amandine Flaig

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A novel dimerization site in non-structural protein 5A of hepatitis C virus regulates viral replication fitness

Paul Rothhaar, Thibault Tubiana, Colin Forster, Gabriel Vanegas Arias, Tomke Arand, Noemi Schäfer, Philipp Ralfs, Christian Heuss, Antonio Piras, Andreas Pichlmair, Xavier Hanoulle, Stéphane Bressanelli, Volker Lohmann

This study identifies a dimerization site in NS5A that enhances HCV replication fitness by promoting self-interaction, which inhibits NS3 and NS5B activity.

PLoS Pathogens · Aug 5, 2026Peer-reviewedMicrobiology

Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.

Fanny Eysert, Audrey Coulon, Emmanuelle Boscher, Anaïs-Camille Vreulx, Amandine Flaig, Tiago Mendes, Sandrine Hughes, Benjamin Grenier‐Boley, Xavier Hanoulle, Florie Demiautte, Charlotte Bauer, Mikael Marttinen, Mari Takalo, Philippe Amouyel, Shruti Desai, , Julien Chapuis

The paper identifies FERMT2 as a key modulator of axon guidance and synaptic plasticity in an APP-dependent manner, linking its genetic risk variant to Alzheimer's disease through miRNA regulation.

Molecular Psychiatry · Nov 3, 2020Peer-reviewedNeuroscience